KEEPL Glyde is backed by
clinical ingredient research

The NIH-funded GAIT trial — the largest clinical trial on glucosamine — demonstrated that Glucosamine Sulfate at 1,500mg per day significantly reduced joint pain in patients with moderate-to-severe knee osteoarthritis. The Sulfate form (not HCl) was specifically identified as the clinically effective variant.

Glucosamine Sulfate promotes the synthesis of glycosaminoglycans, the building blocks of cartilage. Regular supplementation at therapeutic doses has been shown to slow cartilage degradation and support synovial fluid production.

Clegg DO et al. (2006). Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. NEJM. — Richy F et al. (2003). Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis. Arch Intern Med.

Clinical research published in the Journal of Agricultural and Food Chemistry found that hydrolyzed Collagen Type II at doses of 1,000–10,000mg per day significantly improved joint comfort, flexibility, and function in patients with osteoarthritis.

Unlike Type I and III collagen (found in skin and tendons), Type II collagen is the primary structural protein in articular cartilage. Oral supplementation provides the amino acid precursors for cartilage matrix synthesis — directly at the tissue level where joint degradation occurs.

Schauss AG et al. (2012). Effect of the novel low molecular weight hydrolyzed chicken sternal cartilage extract on osteoarthritis-related symptoms. J Agric Food Chem. — Kumar S et al. (2015). A Double-Blind, Placebo-Controlled, Randomised Clinical Study on the Effectiveness of Collagen Peptide on Osteoarthritis. J Sci Food Agric.

A randomized, double-blind, placebo-controlled trial published in Phytomedicine demonstrated that Boswellia Serrata extract at 300mg per day, standardized to 65% Boswellic Acids, significantly reduced knee pain scores and improved physical function within 8 weeks.

Boswellic Acids — particularly AKBA — selectively inhibit the 5-lipoxygenase (5-LOX) enzyme, responsible for the production of pro-inflammatory leukotrienes. This mechanism is distinct from NSAIDs, meaning Boswellia does not carry their gastrointestinal side effects.

Kimmatkar N et al. (2003). Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee. Phytomedicine. — Sengupta K et al. (2010). Comparative efficacy and tolerability of 5-Loxin and Aflapin against osteoarthritis of the knee. Int J Med Sci.

A landmark study published in Planta Medica demonstrated that co-administration of Piperine at just 5mg alongside Curcumin increased serum Curcumin levels by 2,000% in human subjects compared to Curcumin administered alone.

Piperine inhibits hepatic and intestinal glucuronidation — the primary metabolic pathway that eliminates Curcumin — allowing it to remain in the bloodstream long enough to exert its anti-inflammatory effects. Every supplement that lists Curcumin without Piperine delivers a fraction of the claimed dose.

Shoba G et al. (1998). Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers. Planta Med. — Anand P et al. (2007). Bioavailability of curcumin: problems and promises. Mol Pharm.

Clinical research published in Nutrition Journal demonstrated that oral Hyaluronic Acid at 80–200mg per day significantly improved knee joint pain, stiffness, and physical function in adults with mild to moderate knee discomfort over 12 weeks.

Hyaluronic Acid is naturally present at high concentrations in synovial fluid, acting as a lubricant and shock absorber between articular surfaces. Oral HA reaches joint tissue through systemic absorption — supplementing the body's declining endogenous production.

Tashiro T et al. (2012). Oral administration of polymer hyaluronic acid alleviates symptoms of knee osteoarthritis. Nutr J. — Kalman DS et al. (2008). Effect of a natural extract of chicken combs with a high content of hyaluronic acid on pain relief. Nutr J.

A double-blind, placebo-controlled trial published in the Journal of the International Society of Sports Nutrition showed that MSM supplementation significantly reduced exercise-induced oxidative stress and muscle damage markers in recreational runners, while improving recovery time.

MSM is a naturally occurring organosulfur compound. Sulfur is essential for the synthesis of collagen and keratin — the structural proteins of connective tissue. MSM has been shown to inhibit NF-κB activation, a key regulator of inflammatory gene expression.

Nakhostin-Roohi B et al. (2011). Effect of MSM supplementation on exercise-induced oxidative stress. J Pharm Pharmacol. — Pagonis TA et al. (2014). The effect of methylsulfonylmethane on postexercise muscle soreness. J Sports Med Phys Fitness.